The clinic changes generally appearĪfter cartilage degeneration with a slow process, thereby the KBD may be classed as early, stage І, IIĪnd III, according to the severity ( 6). Residents are at risk in endemic areas ( 4, 5).Īt present, diagnosis of KBD remains to be based onĬlinic manifestations and X-ray changes of metaphyseal ( 5). The northeast and southwest regions of China where seleniumĭeficiency has been associated with the disease pathogenesisĠ.66 million KBD patients in China, while less than 30 million Limited movement or potentially dwarfism ( 3), the majority of adult patients partly orĬompletely lose work and self-care ability. KBD isĬharacterized by swelling of digits, deformed limb joints and KBD predominantly presents in 3–12 year old patients. InĬontrast with OA, instead of the middle aged and elderly people, Osteoarthropathy, which is similar with osteoarthritis (OA) inĬlinical manifestation, with pathological features includingĬartilage degeneration, cartilage extracellular matrix degradation,Ĭhondrocyte necrosis and apoptosis ( 1, 2). The present results suggest that there are similarities in vascular microcirculation, immunoreactions and cell apoptosis between KBD and OA, which may contribute to the early diagnosis and pathogenetic study of KBD. Nine common significant pathways and five common differentially expressed genes were found between the two diseases. Nine common significant pathways and five common differentially expressed genes were identified between the KBD and OA.
A total of 82 differentially expressed genes, 51 significant different signaling pathways and five significant biological functions were identified in KBD patient samples, while 89, 50 and five significantly different genes, pathways and functions were identified in OA. Significant different pathways between KBD and OA were analyzed using Ingenuity Pathway Analysis software. The gene expression data of OA were obtained from GEO published database. Total RNAs were extracted and gene expression levels were determined using an Agilent whole genome expression microarrays. A total of 20 and 12 peripheral blood samples were separately collected from KBD patients and normal control subjects, respectively, in an endemic area according to the diagnosis criteria. The aim of the present study was to investigate the early diagnostic biomarkers of Kashin‑Beck disease (KBD), and to compare the common signaling pathways of peripheral mononuclear cells between patients with KBD and those with osteoarthritis (OA).